EpiPLASS

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Platelet-Rich Plasma (PRP) is a progressive non-surgical healing treatment in a variety of fields, including wound management. It is a Bioactive Solution for enhanced tissue formation and remodeling

Product and advantages

PRP is a fraction of autologous plasma with supraphysiological concentration of platelets.Platelets contain α granules, which comprise cytokines, growth factors and bioactive proteins essential for tissue repair and healing. Upon injury, platelets initiate blood coagulation and release growth factors that activate the healing response ( PDGF/ TGF/ VEGF/ EGF etc.) These bioactive proteins initiate connective tissue healing; promoting development of new blood vessels, new epithelization as well as stimulating other cascades in the wound healing process.

  • Optimal biological profile of PRP/PRF due to the unique composed separation gel:
  • High platelet concentration and yield
  • Eliminating undesired erythrocytes, which decrease fibroblast and augment apoptosis in vitro
  • Massive reduction of granulocytes, which mediate catabolic effects
  • Enriching mononuclear cells which induce anabolic effects, increase collagen expression and fight infection
  • Flexibility of system enables user to obtain higher or lower concentration by simply adjusting the amount of clear plasma moved from the PRP tube
  • A closed system to ensure optimal sterility and infection avoidance
  • Short and easy preparation and handling, only 10/15 minutes centrifugation
  • Expensive capital equipment is not required
  • Promising data backed by clinical studies performed by reputable clinicians
  • Pure autologous PRF, no need to add activating substances

Application

  • Initiate and accelerate tissue synthesis, tissue regeneration, bone and joint surface regeneration and promote the development of new blood vessels. As a result, later infectious, complications and discomfort decreases.
  • Minimal safety concerns, non-allergic and free from concerns over transmissible diseases
  • Maybe combined with other treatments to stimulate the biological effect

Chronic Wounds:

  • Diabetic ulcers
  • Venous ulcers
  • Peripheral Arterial Disease
  • Pressure ulcers
  • Traumatic Ulcers
  • Post-Surgical Wounds

Acute Wounds:

  • Open fractures
  • Closed fractures with skin necrosis
  • Friction burns

Brochure

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Literature

  • Application of PRP accelerates the wound healing process in acute and chronic ulcers through paris migration and up regulation of cyclin A and CDK4 in HaCaT cells. Kim et al. Mol Med Rep. 2013
  • Autologous PRP in chronic wounds. Salcido. Adv Skin Wound Care 2013
  • Treatment of Refractory Venous Stasis Ulcers with Autologous PRP and light-emitting diodes: A pilot study. Park et al. J Dermatolog Treat. 2013
  • PRP enhances the dermal regeneration efficacy of human adipose-derived stromal cells administered to skin wounds. Bhang et al. Cell Transplant. 2013
  • Advances in wound healing: A review of current wound healing products. Murphy and Evans. Plast Surgery Int. 2012
  • Evaluation of the potentials of autologous blood injection for healing in diabetic foot ulcers. Al Azrak et al. J Am Coll Clin Wound Spec. 2012
  • PRP versus Platelet Poor Plasma in the management of chronic diabetic foot ulcers: A comparative study. Saad Setta et al. Int Wound J. 2011
  • Application of enhanced stromal vascular fraction and fat grafting mixed with PRP in post-traumatic lower extremity ulcers. Cervelli et al. Stem Cell Research. 2011
  • Use of PRP gel on wound healing: A systematic review and meta-analysis. Carter et al. Eplasty. 2011
  • Enhanced skin wound healing by a sustained release of growth factors contained in PRP. Yang et al. Exp Mol Med. 2011
  • PRP: Support for its use in wound healing. Lacci and Dardik. Yale J Biol Med. Mar 2010
  • PRP in Burns. Pallua et al. Burns. 2010
  • Chronic wounds treated with physiologically relevant concentration of PRP gel: A prospective case series. Frykberg et al. Ostomy Wound Manage. 2010
  • Application of autologous derived PRP gel in treatment of chronic wound ulcers: Diabetic foot ulcer. Akingboye et al. J Extra Corpor Techno. 2010
  • The use of autologous PRP gel as and aid in management of acute trauma wounds. Kazakos et al. Injury, Int. J. Care Injured. 2008
  • Treatment of chronic wounds with autologous PRP. Gürgen. EWMA Journal. 2008
  • Use of platelet growth factors in treating wounds and soft tissue injuries. Rozman and Bolta. Acta Dermatovernol Alp Pannonica Adriat. 2007
  • PRP combined with skin substitute of chronic wound healing: A case report. Knox et al. J Extra Corpor Technol. 2006